Endocrine Abstracts

Introduction: Still there is a discussion about the importance of diagnostic and prognostic relevance BRAFV600E mutation. The wide range of BRAFV600E mutation frequency (40–80%) doesn’t facilitate this task. Population diversity and genotyping methodology are suspected sources of differences seen in the mutation frequencies detected by different studies. The aim of this study was to assess the prevalence BRAF V600...

Introduction: BRAFV600E mutation constitutes 98–99% of all detected mutation in thyroid carcinoma. The remaining 2% are BRAF mutations detected in the vicinity of codon V600. Due to the low incidence not much is known about their importance for the development of papillary thyroid carcinoma (PTC). In addition, some of these mutations co-occur with the mutation BRAFV600E.Methods/design: The study prese...

Introduction: Fine needle aspiration cytology (FNACC) is the basic tool used in the diagnosis of thyroid cancer (TC) in nodular goitre. FNACC does not allow for the establishment of a clear diagnosis in 15–30% of cases (mainly follicular lesions). Molecular biology techniques can be useful, allowing for the detection, in FNACC smears, of the known mutations involved in the oncogenesis.Aim: To evaluate the usefulness of the detection of the BRAF muta...